Prevacid®24HR is powered to relieve frequent heartburn for a full 24 hours—day and night1-3
In 2 clinical trials, Prevacid®24HR significantly increased the percentage of heartburn-free 24-hour days vs placebo during 14 days of treatment*2
Relief starts as early as day 1 and continues over the course of treatment*1,2
The only OTC PPI specifically studied in a nighttime heartburn population||3
In a 3rd clinical trial among people with frequent nighttime heartburn, Prevacid®24HR significantly increased the percentage of heartburn-free nighttimes vs placebo during 14 days of treatment||3
- Study 3: 62% with Prevacid®24HR vs 48% with placebo (P<0.0001)
* Two multicenter, randomized, double-blind, placebo-controlled, parallel-group studies of 14-day treatment with lansoprazole 15 mg once daily in subjects with frequent heartburn (defined as heartburn that occurred ≥2 days per week over the previous month if heartburn was left untreated).
† "Mild symptoms" defined as heartburn that was present but easily tolerated.
¶ Complete relief was a primary end point. The measurement of improvement of symptoms was part of the statistical analysis plan.
|| A multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 14-day treatment with lansoprazole 15 mg or 30 mg once daily. Subjects had frequent heartburn (≥2 days per week over the previous month if heartburn was left untreated), with nighttime heartburn ≥2 days per week over the previous month (nighttime was defined as the period between lying down for sleep and arising from sleep).
† "Mild symptoms" defined as heartburn that was present but easily tolerated.
¶ Complete relief was a primary end point. The measurement of improvement of symptoms was part of the statistical analysis plan.
|| A multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 14-day treatment with lansoprazole 15 mg or 30 mg once daily. Subjects had frequent heartburn (≥2 days per week over the previous month if heartburn was left untreated), with nighttime heartburn ≥2 days per week over the previous month (nighttime was defined as the period between lying down for sleep and arising from sleep).
References
1. Data on file, Novartis Consumer Health, Inc.
2. Kushner PR, Snoddy AM, Gilderman L, Peura DA. Lansoprazole 15 mg once daily for 14 days is effective for treatment of frequent heartburn: results of 2 randomized, placebo-controlled, double-blind studies. Postgrad Med. 2009;121(4):67-75.
3. Peura DA, Riff DS, Snoddy AM, Fennerty MB. Clinical trial: lansoprazole 15 or 30 mg once daily vs placebo for treatment of frequent nighttime heartburn in self-treating subjects. Aliment Pharmacol Ther. 2009;30(5):459-468.
1. Data on file, Novartis Consumer Health, Inc.
2. Kushner PR, Snoddy AM, Gilderman L, Peura DA. Lansoprazole 15 mg once daily for 14 days is effective for treatment of frequent heartburn: results of 2 randomized, placebo-controlled, double-blind studies. Postgrad Med. 2009;121(4):67-75.
3. Peura DA, Riff DS, Snoddy AM, Fennerty MB. Clinical trial: lansoprazole 15 or 30 mg once daily vs placebo for treatment of frequent nighttime heartburn in self-treating subjects. Aliment Pharmacol Ther. 2009;30(5):459-468.
Prevacid® is a registered trademark of Takeda Pharmaceuticals North America, Inc., and is used under license.
© 2009 Novartis Consumer Health, Inc.
© 2009 Novartis Consumer Health, Inc.
